It gives bone marrow the signal to produce red blood cells rbcs, which carry oxygen in the blood. This is an instructional video informing patients how to administer eprex on their own. Eprex 2,000 iuml solution for injection in prefilled syringe. Comparison among erythropoietin stimulating agents full. Eprex epoetin alfa marketing authorisation extended to.
Appropriate dose adjustments should be made to maintain haemoglobin concentrations within the target range of 10 gdl to 12 gdl 6. For patients on peritoneal dialysis eprex may be given twice a week. In these situations they decrease the need for blood transfusions. Sep 26, 2008 the fda announced on friday that it had received preliminary information from an independent study being conducted in germany, which showed patients taking eprex in the high doses, about 40,000. The recommended starting dose is eprex 450 iukg maximum total dose is 40,000 iu administered subcutaneously once every week, with not less than 5 days between doses. Bula do eprex, extraida manualmente da bula em pdf da anvisa. Epoetin alfa is produced naturally in the body, mostly by the kidneys. Composicion, indicaciones, presentacion y contraindicaciones. This shopping feature will continue to load items when the enter key is pressed. Approved name of the medicinal product in braille on the packaging was confirmed.
Search the pharmac website for eprex, or search the collated pharmaceutical schedule, may 2020 alternatively you can try to search the following resources. Keep out of reach of children and petshow much medicine you take and how often you take it depend on many factors, including the condition being treated and the age and weight of the patient. Eprex has been used in many cancer patients and those with renal failure in the united kingdom and throughout the world. Comparative cost efficiency across the european g5. Learn about eprexs dosage, side effects and indications. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Comparative cost efficiency across the european g5 countries. Darbepoetin alfa subjects in that group received darbepoetin alfa once every week or every 2 weeks as per protocol. It is a cytokine for erythrocyte red blood cell precursors in the bone marrow. To evaluate the comparative cost efficiency across the european union g5 countries of the erythropoiesisstimulating agents esas epoetin. You may place an order, item will ship when it becomes available. Eprex, iu0,1ml inj sol isp 6x0,5ml, state institute.
Eprex 2,000 iuml, 4,000 iuml, 10,000 iuml and 40,000 iuml solution for injection in prefilled syringes epoetin alfa read all of this leaflet carefully before you start using this medicine because it contains important information for you. Mar 15, 2011 this is an instructional video informing patients how to administer eprex on their own. This product is permanently discontinued, please consult your doctor. They are used to treat anemia due to end stage kidney disease, chemotherapy, major surgery, or certain treatments in hivaids. It is also used during certain surgeries to decrease the need for blood transfusion. Eprex, iu0,1ml inj sol isp 6x0,5ml, state institute for. Early trials suggest that eprex has an advantage of improving the energy levels and quality of life over the whole chemotherapy course compared to. Eprex is used to treat anaemia in adults with a bone marrow disorder that causes a severe disruption in the creation of blood cells myelodysplastic syndromes. Comparison between short and longacting erythropoiesis. Erythropoiesisstimulating agents esa are medications which stimulate the bone marrow to make red blood cells.
Eprexerypo is a sterile, buffered protein solution for intravenous or subcutaneous injection containing varying quantities of epoetinum alfa between 500 and 10,000 iu formulated in a 0. Many potential causes for prca have been reported, but most concern only isolated case reports, and about 50% of cases have no known cause. Eprex is indicated for the treatment of patients with symptomatic or transfusion requiring anaemia associated with chronic renal failure to improve their quality of life by improving energy 4 eprex 140701 dpi. French approval for eprex for symptomatic anemia 28032017 print. Eprex indicaciones, dosificacion, presentacion, efectos. Article vifor pharma deal furthers akebias commercialization plan. Data sheets and consumer medicine information search for eprex.
Darbepoetin alpha subjects in that group received darbepoetin alfa once every week or every 2 weeks as per protocol. For adults and children eprex is given as an injection either into a vein or a tube that goes into a vein. The ced recommended that epoetin alfa eprex 30,000iu prefilled syringe not be funded on the basis that it is priced the same as the 40,000iu prefilled syringe. Apr 29, 2019 the recommended starting dose is eprex 450 iukg maximum total dose is 40,000 iu administered subcutaneously once every week, with not less than 5 days between doses. Eprex is given alone and not mixed with other liquids for injection. Below are some of the details of erythropoietingeneric erythropoietin, or epo, is a glycoprotein hormone that controls erythropoiesis, or red blood cell production. Eprex comes in packs of six, clear glass vials or prefilled injection syringes, each containing a clear, colourless solution. A significantly greater amount of autologous blood p0. Background the incidence of pure red cell aplasia prca in chronic kidney disease patients treated with epoetins increased substantially in 1998, was shown to be antibody mediated, and was associated predominantly with subcutaneous. Alternatively, a dose of 40,000 to 60,000 units once weekly may be used.
Refer to page 2 for ferrous fumarate or intravenous iron protocol. Eprex erypo is a sterile, buffered protein solution for intravenous or subcutaneous injection containing varying quantities of epoetinum alfa between 500 and 10,000 iu formulated in a 0. Learn about eprex s dosage, side effects and indications. Eprex 40000 iu injection uses, dosage, side effects. Eprex is a medicine which contains epoetin alfa, a hormone that stimulates the bone marrow to produce more red blood cells. Doses of darbepoetin alfa were decreased by 25% for hb values 12 and. Eprex eprex product description store in a dry place at room temperature between 59 86f.
If eprex is injected under the skin subcutaneously, the amount injected. The increased incidence of pure red cell aplasia with an eprex formulation in uncoated rubber stopper syringes. By intravenous injection, or by subcutaneous injection. In order to navigate out of this carousel please use your heading shortcut key to navigate to the next or previous heading. The increased incidence of pure red cell aplasia with an. Based on the ceds recommendation, the executive officer decided to fund epoetin alfa eprex 20,000iu prefilled syringe and not fund the 30,000iu prefilled syringe. It is used to treat anemia caused due to severe kidney disease or cancer medications. Both blood transfusions and eprex are successful in correcting anaemia. Committee to evaluate drugs ced epoetin alfa additional. Includes eprex side effects, interactions and indications. Eprex is synthetic erythropoietin epoetin alfa and is used to increase the production of red blood cells and decrease the need for transfusions of red blood cells. Hb variability was less frequent in the aranesp group p 0. Data sources include ibm watson micromedex updated 4 may 2020, cerner multum updated 4 may 2020, wolters kluwer updated.
481 204 1227 599 1034 1467 639 1178 86 1516 481 1670 1638 1373 677 805 1384 389 814 1636 61 1427 1520 1217 216 1003 933 1057 925 577 1336 526 57